Biofunctional matrix models reveal mineral-dependent mechanoregulation of bone metastatic breast cancer

Siyoung Choi, M. Whitman, Adrian A. Shimpi, Aaron E. Chiou, J. Druso, A. Verma, Stephanie C. Lux, Zhu Cheng, M. Paszek, O. Elemento, L. Estroff, C. Fischbach

bioRxiv, 2022

Breast cancer–secreted factors perturb murine bone growth in regions prone to metastasis

Aaron E. Chiou, Chuang Liu, I. Moreno-Jiménez, Tengteng Tang, W. Wagermaier, M. Dean, C. Fischbach, P. Fratzl

Science Advances, 2021

Fluorescent Silica Nanoparticles to Label Metastatic Tumor Cells in Mineralized Bone Microenvironments.

Aaron E. Chiou, Joshua A. Hinckley, Rupal Khaitan, Neta Varsano, Jonathan Wang, Henry F Malarkey, C. Hernandez, Rebecca M. Williams, L. Estroff, S. Weiner, L. Addadi, U. Wiesner, C. Fischbach

Small, 2020

Direct Comparison of Optical and Electron Microscopy Methods for Structural Characterization of Extracellular Vesicles.

Jade M. Noble, L. M. Roberts, Netta Vidavsky, Aaron E. Chiou, C. Fischbach, M. Paszek, L. Estroff, L. Kourkoutis

Journal of structural biology, 2020

Supported Membrane Platform to Assess Surface Interactions between Extracellular Vesicles and Stromal Cells.

Johana Uribe, Han-Yuan Liu, Zeinab Mohamed, Aaron E. Chiou, C. Fischbach, S. Daniel

ACS biomaterials science & engineering, 2020

Hydroxyapatite mineral enhances malignant potential in a tissue-engineered model of ductal carcinoma in situ (DCIS).

F. He, N. Springer, Matthew A. Whitman, S. Pathi, Yeonkyung Lee, S. Mohanan, Stephen C Marcott, Aaron E. Chiou, Bryant S Blank, N. Iyengar, P. Morris, M. Jochelson, C. Hudis, Pragya Shah, Jennie A M R Kunitake, L. Estroff, J. Lammerding, C. Fischbach

Biomaterials, 2019

Mapping and Profiling Lipid Distribution in a 3D Model of Breast Cancer Progression

Netta Vidavsky, Jennie A M R Kunitake, M. E. Diaz-Rubio, Aaron E. Chiou, Hyun-Chae Loh, Sheng Zhang, A. Masic, C. Fischbach, L. Estroff

ACS central science, 2019

Tissue-Engineered Models for Studies of Bone Metastasis

Aaron E. Chiou, C. Fischbach

2018

Revealing Mechanisms of Microvesicle Biogenesis in Breast Cancer Cells via in situ Microscopy

Jade M. Noble, Netta Vidavsky, LaDiedra Monet Roberts, Aaron E. Chiou, M. Paszek, C. Fischbach, L. Estroff, L. Kourkoutis

Microscopy and Microanalysis, 2018

Studying biomineralization pathways in a 3D culture model of breast cancer microcalcifications.

Netta Vidavsky, Jennie A M R Kunitake, Aaron E. Chiou, P. Northrup, T. Porri, L. Ling, C. Fischbach, L. Estroff

Biomaterials, 2018

Multiscale characterization of the mineral phase at skeletal sites of breast cancer metastasis

F. He, Aaron E. Chiou, Hyun-Chae Loh, M. Lynch, B. R. Seo, Y. Song, Min Joon Lee, Rebecca M Hoerth, Emely L. Bortel, B. Willie, G. Duda, L. Estroff, A. Masic, W. Wagermaier, P. Fratzl, C. Fischbach

Proceedings of the National Academy of Sciences, 2017

Breast cancer-derived extracellular vesicles stimulate myofibroblast differentiation and pro-angiogenic behavior of adipose stem cells.

Y. Song, Christine Warncke, S. Choi, Siyoung Choi, Aaron E. Chiou, L. Ling, Han Liu, S. Daniel, M. Antonyak, R. Cerione, C. Fischbach

Matrix biology : journal of the International Society for Matrix Biology, 2017

Three-Dimensional Mechanical Loading Modulates the Osteogenic Response of Mesenchymal Stem Cells to Tumor-Derived Soluble Signals.

M. Lynch, Aaron E. Chiou, Min Joon Lee, Stephen C Marcott, Praveen V Polamraju, Yeonkyung Lee, C. Fischbach

Tissue engineering. Part A, 2016